Journal article
The dominant Australian community-acquired methicillin-resistant Staphylococcus aureus clone ST93-IV [2B] is highly virulent and genetically distinct
KYL Chua, T Seemann, PF Harrison, S Monagle, TM Korman, PDR Johnson, GW Coombs, BO Howden, JK Davies, BP Howden, TP Stinear
Plos One | Published : 2011
Abstract
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 has spread rapidly across North America, and CA-MRSA is also increasing in Australia. However, the dominant Australian CA-MRSA strain, ST93-IV [2B] appears distantly related to USA300 despite strikingly similar clinical and epidemiological profiles. Here, we compared the virulence of a recent Australian ST93 isolate (JKD6159) to other MRSA, including USA300, and found that JKD6159 was the most virulent in a mouse skin infection model. We fully sequenced the genome of JKD6159 and confirmed that JKD6159 is a distinct clone with 7616 single nucleotide polymorphisms (SNPs) distinguishing this strain from all other ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by the National Health and Medical Research Council of Australia Project Grant 1008656, the CASS Foundation and the Austin Hospital Medical Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.